| Id: | acc4555 |
| Group: | 1sens |
| Protein: | Akt |
| Gene Symbol: | Akt1 |
| Protein Id: | P47196 |
| Protein Name: | AKT1_RAT |
| PTM: | phosphorylation |
| Site: | Thr308 |
| Site Sequence: | GIKDGATMKTFCGTPEYLAPE |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Pulmonary Artery Proliferation |
| Disease Subtype: | 5-HT induced |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | KMUP-1 |
| Drug Info: | KMUP-1 is a novel drug with potential effects in cardiovascular protection and anti - inflammatory activities. It has been investigated for its possible therapeutic applications in relevant pathological conditions. |
| Relation: |
KMUP-1
➜
Akt-Thr308
DOWN
➜
Pulmonary Artery Proliferation
Alleviate
|
| Effect: | modulate |
| Effect Info: | "KMUP-1 inhibits 5-HTT/RhoA/ROCK expression and AKT/ERK phosphorylation, thereby inhibiting MCT-induced pulmonary artery proliferation." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 20870034 |
| Sentence Index: | 20870034_0 |
| Sentence: | "KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation." |
Sequence & Structure:
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| T | 308 | D | Obesity | Phosphorylation | 16267124 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
