| Id: | acc4513 |
| Group: | 1sens |
| Protein: | p53? |
| Gene Symbol: | Tp53 |
| Protein Id: | P02340 |
| Protein Name: | P53_MOUSE |
| PTM: | acetylation |
| Site: | Lys382 |
| Site Sequence: | STSRHKKTMVKKVGPDSD--- |
| Disease Category: | Urinary and reproductive system diseases |
| Disease: | Acute Kidney Injury |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Baicalein? |
| Drug Info: | Baicalein is a flavonoid compound that is extracted from the roots of Scutellaria baicalensis and has various pharmacological activities. |
| Relation: |
Baicalein?
➜
p53?-Lys382
DOWN
➜
Acute Kidney Injury
Alleviate
|
| Effect: | modulate |
| Effect Info: | Baicalein inhibits PMB-induced ferroptosis and alleviates acute kidney injury (AKI) by upregulating SIRT1 expression and reducing the acetylation level of p53 at the K382 site. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 37354967 |
| Sentence Index: | 37354967_0 |
| Sentence: | Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation. |
Sequence & Structure:
MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDLLLPQDVEEFFEGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
