Id: acc4455
Group: 1sens
Protein: Drp1
Gene Symbol: Dnm1l
Protein Id: Q8K1M6
Protein Name: DNM1L_MOUSE
PTM: phosphorylation
Site: Tyr628
Site Sequence: KGHAVNLLDVPVPVARKLSAR
Disease Category: Cardiovascular and circulatory system diseases
Disease: Aortic Valve Calcificatio
Disease Subtype:
Disease Cellline: VICs
Disease Info:
Drug: Folic acid
Drug Info: "Folic acid, a widely used supplement, increases dihydrofolate reductase expression to salvage tetrahydrobiopterin (BH?) bioavailability, thereby alleviating hypercholesterolaemia-induced aortic valve calcification in mice."
Relation:
Folic acid
➜
Drp1-Tyr628 DOWN
➜
Aortic Valve Calcificatio Alleviate
Effect: modulate
Effect Info: Tyrosine nitration of DRP1 promotes valve calcification.
Note:
Score: 4.0
Pubmed(PMID): 35139535
Sentence Index:
Sentence:

Sequence & Structure:

MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAGSRDKSSKVPSALAPASQEPPPAASAEADGKLIQDNRRETKNVPSAGGGIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: