Id: acc4378
Group: 1sens
Protein: PGC1alpha
Gene Symbol: Ppargc1a
Protein Id: Q9QYK2
Protein Name: PRGC1_RAT
PTM: acetylation
Site: Lys
Site Sequence:
Disease Category: Cardiovascular and circulatory system diseases
Disease: Cardiac and Neurological Injuries
Disease Subtype:
Disease Cellline: PC12
Disease Info:
Drug: Ginsenoside Rc
Drug Info: "Ginsenoside Rc is a type of ginsenoside, which is an active component found in ginseng and has various potential health - promoting effects."
Relation:
Ginsenoside Rc
➜
PGC1alpha-Lys UP
➜
Cardiac and Neurological Injuries Alleviate
Effect: modulate
Effect Info: Ginsenoside Rc reduces mitochondrial damage and apoptosis by decreasing PGC1alpha acetylation mediated by SIRT1 restoration.
Note:
Score: 4.0
Pubmed(PMID): 33439015
Sentence Index:
Sentence:

Sequence & Structure:

MAWDMCSQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPANIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHTHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKTVVPPPTKRARYSECSGTQGSHSTKKGPEQSELYAQLSKSSVLSRGHEERKTKRPSLRLFGDHDYCQSVNSKTDILINISQELQDSRQLDFKDASCDWQGHICSSTDSSQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDKVDKTSELRDGNFSNEQFSKLPVFINSGLAMDGLFDDSEDENDKLSYPWDGTQSYSLFDVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEANEHERLKRDEYRREYEKRESERAKQRERQKQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: