| Id: | acc4349 |
| Group: | 1sens |
| Protein: | PP2A |
| Gene Symbol: | Ptpa |
| Protein Id: | P58389 |
| Protein Name: | PTPA_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr307 |
| Site Sequence: | ECLEKFPVIQHFKFGSLLPIH |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Endothelial Dysfunction |
| Disease Subtype: | |
| Disease Cellline: | Sprague–Dawley rat |
| Disease Info: | |
| Drug: | Angiotensin II |
| Drug Info: | Angiotensin II is a peptide hormone that plays a crucial role in regulating blood pressure and fluid balance. It constricts blood vessels and stimulates the release of aldosterone. |
| Relation: |
Angiotensin II
➜
PP2A-Tyr307
DOWN
➜
Endothelial Dysfunction
Aggravate
|
| Effect: | modulate |
| Effect Info: | "AngII activates PP2A by downregulating the phosphorylation of the catalytic subunit Tyr307 of PP2A, thereby reducing eNOS phosphorylation levels and NO content, leading to endothelial dysfunction." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 33162896 |
| Sentence Index: | 33162896_13 |
| Sentence: | The activated PP2A further decreases levels of eNOS Ser1177 phosphorylation and NO content leading to endothelial dysfunction. |
Sequence & Structure:
MAEGERQPPPDSSEETPPTTQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFDYKVSEAIEKLVALLDTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDQEAENLVATVVPTHLAAAVPEVAVYLKEAVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQVAIVFKVFDRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPHLEPRHFVDEKAVSENHKDYMFLQCILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
