| Id: | acc4279 |
| Group: | 1sens |
| Protein: | Drp1 |
| Gene Symbol: | Dnm1l |
| Protein Id: | Q8K1M6 |
| Protein Name: | DNM1L_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser616 |
| Site Sequence: | SKPIPIMPASPQKGHAVNLLD |
| Disease Category: | Nervous system diseases |
| Disease: | Mitochondrial Dysfunction |
| Disease Subtype: | "Mitochondrial Dysfunction, Neuronal Loss" |
| Disease Cellline: | SN4741 |
| Disease Info: | |
| Drug: | mutant A53T alpha-synuclein |
| Drug Info: | "The <|Drug|> is mutant A53T alpha - synuclein, which is a mutant form of alpha - synuclein protein associated with certain pathologies. " |
| Relation: |
mutant A53T alpha-synuclein
➜
Drp1-Ser616
UP
➜
Mitochondrial Dysfunction
Aggravate
|
| Effect: | modulate |
| Effect Info: | "Mutations lead to DRP1 phosphorylation, promoting mitochondrial dysfunction and neuronal damage." |
| Note: | Non-conventional drugs |
| Score: | 3.0 |
| Pubmed(PMID): | 31881179 |
| Sentence Index: | 31881179_3 |
| Sentence: | "Here, we demonstrate that dynamin-related protein 1(DRP1) is a substrate for p38 MAPK, mutant alpha-synuclein overexpression in SN4741 cell caused p38 MAPK activation, p38 MAPK-mediated phosphorylation DRP1 at serine 616 to activate DRP1 and is associated with increased mitochondrial fission, which resulted in mitochondrial dysfunction and neuronal loss." |
Sequence & Structure:
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAGSRDKSSKVPSALAPASQEPPPAASAEADGKLIQDNRRETKNVPSAGGGIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
