| Id: | acc4265 |
| Group: | 1sens |
| Protein: | ERK |
| Gene Symbol: | Mapk1 |
| Protein Id: | P21708 |
| Protein Name: | MK03_RAT |
| PTM: | phosphorylation |
| Site: | Tyr204 |
| Site Sequence: | EHDHTGFLTEYVATRWYRAPE |
| Disease Category: | Nervous system diseases |
| Disease: | Neuropathic Pain |
| Disease Subtype: | oxaliplatin-induced |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Oxaliplatin |
| Drug Info: | "Oxaliplatin is a third-generation platinum-based chemotherapy drug primarily used to treat colorectal cancer, both as adjuvant therapy after surgery and for metastatic disease. It functions by forming DNA cross-links that inhibit DNA replication and transcription, ultimately inducing cancer cell death." |
| Relation: |
ERK-Tyr204
DOWN
＋
Oxaliplatin
➜
Neuropathic Pain
Alleviate
|
| Effect: | inhibit |
| Effect Info: | ERK inhibitor PD98059 inhibits oxaliplatin-induced ERK phosphorylation and neuropathic pain. |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 31765435 |
| Sentence Index: | 31765435_10 |
| Sentence: | Administration of ERK inhibitor PD98059 (6 mug day-1 intrathecally) inhibited oxaliplatin-induced ERK phosphorylation and neuropathic pain. |
Sequence & Structure:
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEAP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
