| Id: | acc4263 |
| Group: | 1sens |
| Protein: | SIRT3 |
| Gene Symbol: | SIRT3 |
| Protein Id: | Q9NTG7 |
| Protein Name: | SIR3_HUMAN |
| PTM: | ubiquitination |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Polycystic Ovarian Syndrome |
| Disease Subtype: | insulin resistance |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Berberine |
| Drug Info: | - |
| Relation: |
Berberine
➜
SIRT3-unclear
UP
➜
Polycystic Ovarian Syndrome
Alleviate
|
| Effect: | promote |
| Effect Info: | "Berberine significantly promotes the ubiquitination and degradation of SIRT3 and regulates autophagy-related functions by activating the FOXO3a/Parkin pathway, thereby improving insulin sensitivity in patients with polycystic ovary syndrome (PCOS)." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 31706105 |
| Sentence Index: | 31706105_3 |
| Sentence: | "This study unveiled a new mechanism by which berberine promotes ovarian cell glucose uptake, and demonstrated that SIRT3 ubiquitination is involved in the insulin sensitizing effect of berberine." |
Sequence & Structure:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
