| Id: | acc4260 |
| Group: | 1sens |
| Protein: | GSK3alpha |
| Gene Symbol: | Gsk3a |
| Protein Id: | Q2NL51 |
| Protein Name: | GSK3A_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser21 |
| Site Sequence: | GGSGRARTSSFAEPGGGGGGG |
| Disease Category: | Musculoskeletal system diseases |
| Disease: | Myopathic Conditions |
| Disease Subtype: | |
| Disease Cellline: | C2C12? |
| Disease Info: | |
| Drug: | Lithium? |
| Drug Info: | "Lithium is a drug commonly used to treat bipolar disorder, helping to stabilize mood swings." |
| Relation: |
Lithium?
➜
GSK3alpha-Ser21
UP
➜
Myopathic Conditions
Alleviate
|
| Effect: | modulate |
| Effect Info: | "Low-dose lithium salts significantly promote the phosphorylation of GSK3alpha at the Ser21 site, inhibit its activity, and enhance myogenic differentiation and cell fusion." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 31671858 |
| Sentence Index: | 31671858_2 |
| Sentence: | "Lithium, a common medication for bipolar disorder, inhibits GSK3 via Mg+ competition and increased Ser21 (GSK3alpha) or Ser9 (GSK3beta) phosphorylation, leading to enhanced myoblast fusion and myogenic differentiation." |
Sequence & Structure:
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATVGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPAGPASPLTTSYNPSSQALTEAQTGQDWQPSDATTATLASSS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
