| Id: | acc4218 |
| Group: | 1sens |
| Protein: | MUS81 |
| Gene Symbol: | MUS81 |
| Protein Id: | Q96NY9 |
| Protein Name: | MUS81_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser87 |
| Site Sequence: | DERLQRHRTSGGDHAPDSPSG |
| Disease Category: | Other |
| Disease: | Excessive Mitotic Abnormalities |
| Disease Subtype: | |
| Disease Cellline: | AG11395 |
| Disease Info: | |
| Drug: | Camptothecin |
| Drug Info: | "Camptothecin is a natural alkaloid with anti - tumor properties, which can inhibit the activity of topoisomerase I." |
| Relation: |
Camptothecin
➜
MUS81-Ser87
UP
➜
Excessive Mitotic Abnormalities
Alleviate
|
| Effect: | modulate |
| Effect Info: | "After treatment with camptothecin, CHK1 phosphorylation is enhanced and MUS81 phosphorylation at the Ser88 site is elevated, which is critical for preventing excessive mitotic abnormalities." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 31114910 |
| Sentence Index: | 31114910_9 |
| Sentence: | "Notably, in WRN exonuclease-deficient cells, persistence of RAD51 correlates with elevated mitotic phosphorylation of MUS81 at Ser87, which is essential to prevent excessive mitotic abnormalities." |
Sequence & Structure:
MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSARPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
