| Id: | acc4141 |
| Group: | 1sens |
| Protein: | AMPK |
| Gene Symbol: | Prkaa1 |
| Protein Id: | P54645 |
| Protein Name: | AAPK1_RAT |
| PTM: | phosphorylation |
| Site: | Thr183 |
| Site Sequence: | MMSDGEFLRTSCGSPNYAAPE |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cerebral Ischemia |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Puerarin |
| Drug Info: | Puerarin is a natural isoflavone compound commonly extracted from Pueraria lobata. It is often used to treat cardiovascular and cerebrovascular diseases. |
| Relation: |
Puerarin
➜
AMPK-Thr183
DOWN
➜
Cerebral Ischemia
Alleviate
|
| Effect: | modulate |
| Effect Info: | Puerarin inhibits autophagy via the AMPK-mTOR-ULK1 signaling pathway to protect the rat brain from ischemia/reperfusion injury. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 29926825 |
| Sentence Index: | 29926825_1 |
| Sentence: | "Puerarin suppresses autophagy to alleviate cerebral ischemia/reperfusion injury, and accumulating evidence indicates that the AMPK-mTOR signaling pathway regulates the activation of the autophagy pathway through the coordinated phosphorylation of ULK1." |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSEVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
