| Id: | acc4068 |
| Group: | 1sens |
| Protein: | Drp1 |
| Gene Symbol: | Dnm1l |
| Protein Id: | O35303 |
| Protein Name: | DNM1L_RAT |
| PTM: | phosphorylation |
| Site: | Ser616 |
| Site Sequence: | NWRGMLKTSKAEELLAEEKSK |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Myocardial Injury |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Melatonin |
| Drug Info: | Melatonin is a hormone that regulates the sleep - wake cycle and is commonly used as a sleep aid. |
| Relation: |
Melatonin
➜
Drp1-Ser616
UP
➜
Myocardial Injury
Alleviate
|
| Effect: | modulate |
| Effect Info: | "Melatonin treatment reduces Drp1 phosphorylation, inhibits mitochondrial Drp1 translocation and mitochondrial fission, and contributes to alleviating myocardial injury and improving cardiac function." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 29024001 |
| Sentence Index: | 29024001_8 |
| Sentence: | "Melatonin treatment at the dose of 30 mg/kg reduced serine 616 phosphorylation of Drp1 and inhibited mitochondrial Drp1 translocation and mitochondrial fission in the hearts of rats subjected to MT, which contributed to the reduction of myocardial injury and the improvement of cardiac function." |
Sequence & Structure:
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENDPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDNRRETKNVASAGGGIGDGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
