| Id: | acc4044 |
| Group: | 1sens |
| Protein: | AMPK |
| Gene Symbol: | Prkaa1 |
| Protein Id: | P54645 |
| Protein Name: | AAPK1_RAT |
| PTM: | phosphorylation |
| Site: | Thr183 |
| Site Sequence: | MMSDGEFLRTSCGSPNYAAPE |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Myocardial Infarction |
| Disease Subtype: | diabetes mellitus |
| Disease Cellline: | H9c2 |
| Disease Info: | |
| Drug: | A-769662 |
| Drug Info: | A-769662 is a drug. It may have potential effects on specific physiological processes. |
| Relation: |
A-769662
➜
AMPK-Thr183
UP
➜
Myocardial Infarction
Alleviate
|
| Effect: | decrease |
| Effect Info: | "When used in combination with IPO, the AMPK activator A-769662 significantly increases AMPK phosphorylation in the myocardium of diabetic rats, reduces mTOR phosphorylation, and provides cardiac protection." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 28765969 |
| Sentence Index: | 28765969_6 |
| Sentence: | "In diabetic rats the myocardial infarct size, and creatine kinase-MB and malondialdehyde release, were increased compared with non-diabetic rats, concomitant with increased cardiac dysfunction and decreased cardiac superoxide dismutase activity, AMPK phosphorylation and autophagy following IR." |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSEVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
