| Id: | acc3967 |
| Group: | 1sens |
| Protein: | occludin |
| Gene Symbol: | Ocln |
| Protein Id: | Q61146 |
| Protein Name: | OCLN_MOUSE |
| PTM: | glycosylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | Diabetic Brain Infarct |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | N-acetylcysteine |
| Drug Info: | N - acetylcysteine is a medication commonly used as a mucolytic agent and an antidote for acetaminophen overdose. |
| Relation: |
N-acetylcysteine
➜
occludin-unclear
DOWN
➜
Diabetes Mellitus
Alleviate
|
| Effect: | modulate |
| Effect Info: | "N-acetylcysteine (NAC) can improve the MG/GSH ratio, reduce the area of cerebral infarction, occludin glycosylation, and blood-brain barrier permeability in diabetic rats, thereby alleviating brain damage caused by ischemia-reperfusion." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 27083477 |
| Sentence Index: | 27083477_14 |
| Sentence: | "N-acetylcysteine (NAC) corrected MG-to-GSH ratio, and reduced diabetic brain infarct area, occludin glycation and permeability." |
Sequence & Structure:
MSVRPFESPPPYRPDEFKPNHYAPSNDMYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTGLFGGSLNYPYSGFGYGGGYGGGYGGYGYGYGGYTDPRAAKGFLLAMAAFCFIASLVIFVTSVIRSGMSRTRRYYLIVIIVSAILGIMVFIATIVYIMGVNPTAQASGSMYGSQIYMICNQFYTPGGTGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKNVSAGTQDMPPPPSDYAERVDSPMAYSSNGKVNGKRSYPESFYKSTPLVPEVAQEIPLTLSVDDFRQPRYSSNGNLETPSKRAPTKGKAGKGKRTDPDHYETDYTTGGESCEELEEDWVREYPPITSDQQRQLYKRNFDAGLQEYKSLQAELDDVNKELSRLDKELDDYREESEEYMAAADEYNRLKQVKGSADYKSKRNYCKQLKSKLSHIKRMVGDYDRRKP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
