| Id: | acc3818 |
| Group: | 1sens |
| Protein: | JNK |
| Gene Symbol: | Mapk8 |
| Protein Id: | Q91Y86 |
| Protein Name: | MK08_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr185 |
| Site Sequence: | AGTSFMMTPYVVTRYYRAPEV |
| Disease Category: | Nervous system diseases |
| Disease: | Cognitive Abnormalities |
| Disease Subtype: | Cognitive Impairment |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Lotus seedpod procyanidins |
| Drug Info: | Lotus seedpod procyanidins are a type of plant-derived compound that may have various health benefits. |
| Relation: |
Lotus seedpod procyanidins
➜
JNK-Tyr185
DOWN
➜
Cognitive Abnormalities
Alleviate
|
| Effect: | modulate |
| Effect Info: | "LSPCs can reverse JNK overphosphorylation caused by exposure to extremely low frequency electromagnetic fields and restore ERK/CREB phosphorylation levels, thereby exerting neuroprotective or memory-enhancing effects" |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 25066354 |
| Sentence Index: | 25066354_0 |
| Sentence: | "Extremely low frequency electromagnetic field exposure causes cognitive impairment associated with alteration of the glutamate level, MAPK pathway activation and decreased CREB phosphorylation in mice hippocampus: reversal by procyanidins extracted from the lotus seedpod." |
Sequence & Structure:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
