| Id: | acc3560 |
| Group: | 1sens |
| Protein: | Akt |
| Gene Symbol: | Akt1 |
| Protein Id: | P47196 |
| Protein Name: | AKT1_RAT |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Pulmonary Hypertension |
| Disease Subtype: | "Pulmonary Arterial Hypertension, monocrotaline in |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Ang-(1-7) |
| Drug Info: | Ang-(1-7) is a bioactive peptide with potential therapeutic effects in cardiovascular and other physiological systems. It may play a role in regulating blood pressure and protecting against certain diseases. |
| Relation: |
Ang-(1-7)
➜
Akt-unclear
DOWN
➜
Pulmonary Hypertension
Alleviate
|
| Effect: | modulate |
| Effect Info: | Ang–(1–7) prevents MCT-induced pulmonary hypertension and vascular remodeling by upregulating eNOS activation through the Akt pathway. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 21381494 |
| Sentence Index: | 21381494_5 |
| Sentence: | "RESULTS: After four weeks, in PAH group, right ventricular systolic pressure (RVSP), right ventricular hypertrophy index (RVHI), percentage of wall thickness (WT%) and percentage of wall area (WA%) were significantly increased, and the level of endothelial nitric oxide synthase (eNOS) protein, eNOS ser 1177-phosphorylati, Akt-phosphorylation were significantly decreased compared with control group." |
Sequence & Structure:
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 473 | D | Major depressive disorder | Phosphorylation | 16959794 |
| S | 473 | D | Type 2 diabetes | Phosphorylation | 34057658 ; 36374861 |
| T | 308 | D | Obesity | Phosphorylation | 16267124 |
| S | 473 | U | Status epilepticus | Phosphorylation | 35562960 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
