| Id: | acc3528 |
| Group: | 1sens |
| Protein: | GluR6 |
| Gene Symbol: | Grik2 |
| Protein Id: | P42260 |
| Protein Name: | GRIK2_RAT |
| PTM: | phosphorylation |
| Site: | Ser |
| Site Sequence: | |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cerebral Ischemia |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | L-VGCC |
| Drug Info: | L-VGCC stands for L-type voltage-gated calcium channel. It is crucial in regulating calcium ion influx in cells and is a target for some drugs in the treatment of various conditions such as hypertension. |
| Relation: |
L-VGCC
➜
GluR6-Ser
DOWN
➜
Cerebral Ischemia
Alleviate
|
| Effect: | modulate |
| Effect Info: | "CaMKII inhibitor KN–93, NMDA receptor antagonist MK801, and L-type calcium channel blocker nifedipine can inhibit the assembly of the GluR6–PSD95–CaMKII signaling module and GluR6 phosphorylation, thereby alleviating neurological damage after cerebral ischemia/reperfusion." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 20888327 |
| Sentence Index: | 20888327_0 |
| Sentence: | Calcium/calmodulin-dependent kinase II facilitated GluR6 subunit serine phosphorylation through GluR6-PSD95-CaMKII signaling module assembly in cerebral ischemia injury. |
Sequence & Structure:
MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
