Id: acc3483
Group: 1sens
Protein: p65
Gene Symbol: Rela
Protein Id: P58546
Protein Name: MTPN_HUMAN
PTM: phosphorylation
Site: Ser536
Site Sequence: ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Disease Category: Endocrine and metabolic diseases
Disease: Diabetes Mellitus
Disease Subtype: STZ induced
Disease Cellline:
Disease Info:
Drug: arjunolic acid
Drug Info: Streptozotocin is a chemotherapeutic agent used in the treatment of pancreatic cancer. | Arjunolic acid has various pharmacological activities such as anti - inflammatory and antioxidant properties.
Relation:
arjunolic acid
➜
p65-Ser536 DOWN
➜
Diabetes Mellitus Aggravate
Effect: modulate
Effect Info: "STZ exposure led to increased concentrations of phosphorylated ERK, phosphorylated JNK, and phosphorylated p38 immune responses in diabetic spleen tissue. This can be reduced by AA treatment, which can prevent hyperglycemia and its associated pathological changes."
Note:
Score: 4.0
Pubmed(PMID): 20053369
Sentence Index:
Sentence:

Sequence & Structure:

MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: