| Id: | acc3432 |
| Group: | 1sens |
| Protein: | PDK1 |
| Gene Symbol: | Pdk1 |
| Protein Id: | Q8BFP9 |
| Protein Name: | PDK1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser504 |
| Site Sequence: | --------------------------------------------------------------------------------- |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Insulin Resistance |
| Disease Subtype: | |
| Disease Cellline: | C2C12 |
| Disease Info: | |
| Drug: | Palmitate |
| Drug Info: | Palmitate is a type of fatty acid ester that may be used in various medical and pharmaceutical applications. |
| Relation: |
Palmitate
➜
PDK1-Ser504
DOWN
➜
Insulin Resistance
Aggravate
|
| Effect: | modulate |
| Effect Info: | Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 19047061 |
| Sentence Index: | 19047061_5 |
| Sentence: | "Akt phosphorylation at Thr308 in the activation loop is reduced in C2C12 myotubes treated with palmitate or overexpressing protein kinase C theta (PKCtheta), a kinase that has been implicated in hyperlipidemia-induced insulin resistance." |
Sequence & Structure:
MRLARLLRGGTSVRPLCAVPCASRSLASASASGSGPASELGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKTIYEFTDTVIRIRNRHNDVIPTMAQGVTEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGSPSHRKHIGSINPNCDVVEVIKDGYENARRLCDLYYVNSPELELEELNAKSPGQTIQVVYVPSHLYHMVFELFKNAMRATMEHHADKGVYPPIQVHVTLGEEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESVERLPVYNKAAWKHYKANHEADDWCVPSREPKDMTTFRSS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
