Id: acc3409
Group: 1sens
Protein: STAT4?
Gene Symbol: Stat4
Protein Id: P42228
Protein Name: STAT4_MOUSE
PTM: ubiquitination
Site: unclear
Site Sequence:
Disease Category: Immune system diseases
Disease: Experimental Autoimmune Encephalomyelitis (Eae)
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: Berbamine
Drug Info: "Berbamine (BM) is a drug with potential therapeutic applications, which may have certain effects on relevant diseases."
Relation:
Berbamine
➜
STAT4?-unclear UP
➜
Experimental Autoimmune Encephalomyelitis (Eae) Aggravate
Effect: modulate
Effect Info: "BM upregulates SLIM (an E3 ubiquitin ligase of STAT4), promoting its ubiquitination and degradation, thereby reducing IFN-gamma production in CD4+ T cells and significantly alleviating the inflammatory response in experimental autoimmune encephalomyelitis (EAE)."
Note:
Score: 4.0
Pubmed(PMID): 18606704
Sentence Index:
Sentence:

Sequence & Structure:

MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIETQDWEVASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPIQGPLEKSLQSSSVSERQRNVEHKVSAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQGDKNSILVNQEVLTLLQEMLNSLDFKRKEALSKMTQIVNETDLLMNSMLLEELQDWKKRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRQQLEKLQEQSTKMTYEGDPIPAQRAHLLERATFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTHVKAMSSEESSNGSLSVEFRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGRGLNSEQLNMLAEKLTVQSNYNDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHSVEPYNKGRLSALAFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPQSPSDLLPMSPSAYAVLRENLSPTTIETAMNSPYSAE

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: