| Id: | acc3328 |
| Group: | 1sens |
| Protein: | eIF2alpha |
| Gene Symbol: | Eif2a |
| Protein Id: | Q8BJW6 |
| Protein Name: | EIF2A_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser51 |
| Site Sequence: | YTFSKDGTLFAWSNGEKVNII |
| Disease Category: | Infectious diseases |
| Disease: | Viral Infection |
| Disease Subtype: | |
| Disease Cellline: | MEF |
| Disease Info: | |
| Drug: | Thapsigargin |
| Drug Info: | Thapsigargin is a well - known drug often used in biological research as an inhibitor of the sarco/endoplasmic reticulum Ca?? - ATPase (SERCA) pumps. |
| Relation: |
Thapsigargin
➜
eIF2alpha-Ser51
UP
➜
Viral Infection
Alleviate
|
| Effect: | modulate |
| Effect Info: | "In the early stage of virus infection, thapsigargin was used to induce the phosphorylation of eIF2alpha protein. The results showed that the protein translation of both the virus and the host was inhibited." |
| Note: | ID not sure |
| Score: | 4.0 |
| Pubmed(PMID): | 15705563 |
| Sentence Index: | 15705563_6 |
| Sentence: | "Induction of eIF2alpha phosphorylation at early times of viral infection by treatment with thapsigargin showed that virus and host translation are similarly inhibited, demonstrating that viral and host messages are similarly sensitive to eIF2alpha phosphorylation." |
Sequence & Structure:
MAPSTPLLTVRGSEGLYMVNGPPHFTESTVLPRESGRNCKVYTFSKDGTLFAWSNGEKVNIINVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDGTAGTPNLQLYDMKTGACLKSFIQKKMQNWCPSWSDDEIICARNVNNEVHFFENNNFNTIANKLHLQKVNDFNLSPGTQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPQAALANKSFFKADKVTMLWNKKATAVLVIASTEVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAFYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSLLHKYDVPSNGELWQVSWQPFLDGIFPAKTIKYQAVPSEVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPHPGSDKPLSKTALKNQRKHEAKKAAKQEARSDAAPTPVPQSAPRNTVTQSASGDPEVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKETALLQELEDLELGV
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
