| Id: | acc3283 |
| Group: | 1sens |
| Protein: | Bcl-2 |
| Gene Symbol: | Bcl2 |
| Protein Id: | P49950 |
| Protein Name: | BCL2_RAT |
| PTM: | phosphorylation |
| Site: | Ser87 |
| Site Sequence: | NAGPALSPVPPVVHLTLRRAG |
| Disease Category: | Nervous system diseases |
| Disease: | Neuronal Death |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Kainic acid |
| Drug Info: | Kainic acid is a potent neuroexcitatory amino acid that can act as an agonist at kainate receptors in the brain. It is commonly used in neuroscience research to induce seizures and study neural pathways. |
| Relation: |
Kainic acid
➜
Bcl-2-Ser87
UP
➜
Neuronal Death
Aggravate
|
| Effect: | modulate |
| Effect Info: | "In kainic acid-mediated neuronal death in the rat brain, the phosphorylation of Bcl-2 increases." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 12956712 |
| Sentence Index: | 12956712_0 |
| Sentence: | Increase in Bcl-2 phosphorylation and reduced levels of BH3-only Bcl-2 family proteins in kainic acid-mediated neuronal death in the rat brain. |
Sequence & Structure:
MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDTGDEDSAPLRAAPTPGIFSFQPESNRTPAVHRDTAARTSPLRPLVANAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
