Id: acc3272
Group: 1sens
Protein: MSH6
Gene Symbol: MSH6
Protein Id: P52701
Protein Name: MSH6_HUMAN
PTM: phosphorylation
Site: unclear
Site Sequence:
Disease Category: Other
Disease: Repair of DNA Damage
Disease Subtype:
Disease Cellline: HeLa-MR
Disease Info:
Drug: Quercetin
Drug Info: -
Relation:
Quercetin
➜
MSH6-unclear DOWN
➜
Repair of DNA Damage Aggravate
Effect: modulate
Effect Info: Phosphorylation of mismatch repair proteins MSH2 and MSH6 affects the mismatch-binding activity of MutSalpha.
Note:
Score: 4.0
Pubmed(PMID): 11972333
Sentence Index:
Sentence:

Sequence & Structure:

MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPLARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRRSSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPVKVARKRKRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAPQNSESQAHVSGGGDDSSRPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPMCRPVILLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

MSH6-Ser137
Cancer Intensity
BRCA -0.767
COAD 0.129
HGSC 0.727
ccRCC 0.411
GBM 0.392
HNSC -0.099
LUAD 0.237
LUSC -2.596
non_ccRCC 0.931
PDAC 0.897
UCEC -0.263
MSH6-Ser14
Cancer Intensity
BRCA -1.063
COAD 1.02
HGSC -1.14
ccRCC 0.393
GBM -1.693
HNSC 0.444
LUAD 0.416
LUSC -0.934
non_ccRCC 0.927
PDAC 1.009
UCEC 0.622
MSH6-Ser200
Cancer Intensity
BRCA -0.509
COAD
HGSC -2.5
ccRCC 0.911
GBM 0.381
HNSC 0.584
LUAD 0.542
LUSC -0.577
non_ccRCC 0.346
PDAC 0.199
UCEC 0.624
MSH6-Ser219
Cancer Intensity
BRCA -2.427
COAD
HGSC
ccRCC 0.347
GBM 0.012
HNSC 0.154
LUAD 0.018
LUSC -0.07
non_ccRCC 1.294
PDAC 0.508
UCEC 0.165
MSH6-Ser227
Cancer Intensity
BRCA -1.561
COAD 0.456
HGSC -2.059
ccRCC 0.535
GBM -0.134
HNSC 0.057
LUAD 0.129
LUSC -0.094
non_ccRCC 1.385
PDAC 0.777
UCEC 0.509
MSH6-Ser252
Cancer Intensity
BRCA
COAD -0.18
HGSC -1.746
ccRCC 1.109
GBM -0.774
HNSC 1.199
LUAD 0.131
LUSC -1.285
non_ccRCC 0.201
PDAC 0.815
UCEC 0.531
MSH6-Ser254
Cancer Intensity
BRCA
COAD -1.791
HGSC 0.159
ccRCC
GBM 0.465
HNSC 0.457
LUAD 1.174
LUSC -0.886
non_ccRCC
PDAC
UCEC 0.422
MSH6-Ser256
Cancer Intensity
BRCA
COAD 0.706
HGSC -1.733
ccRCC
GBM
HNSC 0.642
LUAD 0.291
LUSC -0.658
non_ccRCC
PDAC
UCEC 0.753
MSH6-Ser261
Cancer Intensity
BRCA -1.277
COAD 0.578
HGSC -0.719
ccRCC 0.943
GBM 0.099
HNSC 0.075
LUAD -0.183
LUSC -2.076
non_ccRCC 0.736
PDAC 1.09
UCEC 0.734
MSH6-Ser274
Cancer Intensity
BRCA
COAD 0.707
HGSC -0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
MSH6-Ser275
Cancer Intensity
BRCA
COAD 0.707
HGSC -0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
MSH6-Ser309
Cancer Intensity
BRCA -0.305
COAD
HGSC 2.127
ccRCC -0.324
GBM 0.367
HNSC -0.084
LUAD -0.896
LUSC -1.71
non_ccRCC 0.386
PDAC -0.067
UCEC 0.506
MSH6-Ser41
Cancer Intensity
BRCA 0.095
COAD -0.082
HGSC -0.608
ccRCC -0.084
GBM 1.319
HNSC 1.909
LUAD 0.234
LUSC -1.898
non_ccRCC -0.645
PDAC 0.125
UCEC -0.365
MSH6-Ser43
Cancer Intensity
BRCA -0.045
COAD -0.06
HGSC 2.529
ccRCC 0.008
GBM 0.49
HNSC 0.267
LUAD -1.049
LUSC -1.41
non_ccRCC -0.342
PDAC -0.148
UCEC -0.24
MSH6-Ser79
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC 0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC -0.707
MSH6-Ser830
Cancer Intensity
BRCA -0.169
COAD 0.228
HGSC 1.839
ccRCC 0.722
GBM -0.607
HNSC -0.019
LUAD -1.451
LUSC -1.424
non_ccRCC
PDAC 0.693
UCEC 0.189
MSH6-Ser87
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC 1.128
LUAD -0.778
LUSC
non_ccRCC
PDAC
UCEC -0.35
MSH6-Ser91
Cancer Intensity
BRCA 0.33
COAD 0.731
HGSC -2.042
ccRCC 0.539
GBM -0.032
HNSC
LUAD
LUSC -0.389
non_ccRCC
PDAC
UCEC 0.863
MSH6-Ser935
Cancer Intensity
BRCA -0.925
COAD
HGSC 1.421
ccRCC
GBM
HNSC
LUAD
LUSC -0.273
non_ccRCC
PDAC
UCEC -0.223
MSH6-Thr305
Cancer Intensity
BRCA -0.21
COAD
HGSC
ccRCC -0.182
GBM -0.274
HNSC -0.463
LUAD -1.463
LUSC
non_ccRCC
PDAC 1.04
UCEC 1.553
MSH6-Thr86
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC 0.707
LUAD -0.707
LUSC
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: