| Id: | acc3174 |
| Group: | 2sens |
| Protein: | AMPK |
| Gene Symbol: | Prkaa2 |
| Protein Id: | Q8BRK8 |
| Protein Name: | AAPK2_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr172 |
| Site Sequence: | MMSDGEFLRTSCGSPNYAAPE |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Hyperlipidemia? |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Rosmarinic Acid |
| Drug Info: | "Rosmarinic Acid is a natural phenolic compound that has antioxidant, anti - inflammatory, and antimicrobial properties. It is often found in plants such as rosemary and mint." |
| Relation: |
Rosmarinic Acid
➜
AMPK-Thr172
UP
➜
Hyperlipidemia?
Alleviate
|
| Effect: | modulate |
| Effect Info: | "Compared with mice fed a normal diet, mice fed a high-fat diet (HFD) had significantly lower levels of phosphorylated AMPK, while HFD-fed mice treated with rosmarinic acid had elevated levels of phosphorylated AMPK, indicating that rosmarinic acid activates the AMPK pathway, promotes fatty acid beta-oxidation, and reduces blood lipids." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 34680102 |
| Sentence Index: | 34680102_6-7 |
| Sentence: | "Our results indicated that rosmarinic acid treatment significantly decreased body weight, blood glucose, and plasma total cholesterol and triglyceride levels in HFD-fed mice. Rosmarinic acid increased the expression levels of cholesterol uptake-associated receptors in liver tissues, including scavenger receptor B type 1 (SR-B1) and low-density lipoprotein receptor (LDL-R)." |
Sequence & Structure:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPDYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKACDIMAEVYRAMKQLGFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDSRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRARSSFDSSTAENHSLSGSLTGSLTGSTLSSASPRLGSHTMDFFEMCASLITALAR
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| T | 172 | U | Cardiomyopathy | Phosphorylation | 37733758 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
