| Id: | acc3173 |
| Group: | 2sens |
| Protein: | AMPK |
| Gene Symbol: | Prkaa1 |
| Protein Id: | Q5EG47 |
| Protein Name: | AAPK1_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr183 |
| Site Sequence: | MMSDGEFLRTSCGSPNYAAPE |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Hyperlipidemia? |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Rosmarinic Acid |
| Drug Info: | "Rosmarinic Acid is a natural phenolic compound that has antioxidant, anti - inflammatory, and antimicrobial properties. It is often found in plants such as rosemary and mint." |
| Relation: |
Rosmarinic Acid
➜
AMPK-Thr183
UP
➜
Hyperlipidemia?
Alleviate
|
| Effect: | modulate |
| Effect Info: | "Compared with mice fed a normal diet, mice fed a high-fat diet (HFD) had significantly lower levels of phosphorylated AMPK, while HFD-fed mice treated with rosmarinic acid had elevated levels of phosphorylated AMPK, indicating that rosmarinic acid activates the AMPK pathway, promotes fatty acid beta-oxidation, and reduces blood lipids." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 34680102 |
| Sentence Index: | 34680102_6-7 |
| Sentence: | "Our results indicated that rosmarinic acid treatment significantly decreased body weight, blood glucose, and plasma total cholesterol and triglyceride levels in HFD-fed mice. Rosmarinic acid increased the expression levels of cholesterol uptake-associated receptors in liver tissues, including scavenger receptor B type 1 (SR-B1) and low-density lipoprotein receptor (LDL-R)." |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRAAIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSDVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
