Id: acc2096
Group: 2sens
Protein: MMP-9
Gene Symbol: MMP9
Protein Id: P14780
Protein Name: MMP9_HUMAN
PTM: phosphorylation
Site: unclear
Site Sequence:
Disease Category: Cancer
Disease: Breast Cancer
Disease Subtype:
Disease Cellline: MCF7
Disease Info:
Drug: SFN
Drug Info: -
Relation:
SFN
➜
MMP-9-unclear DOWN
➜
Breast Cancer Alleviate
Effect: modulate
Effect Info: SFN may inhibit breast cancer progression by regulating the NF-kappaB/MMP-9 (inhibition) signaling pathway.
Note: site unclear
Score: 4.0
Pubmed(PMID): 35988280
Sentence Index:
Sentence:

Sequence & Structure:

MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
MMP9 ANDECALIXIMAB Matrix metalloproteinase 9 inhibitor 3 Completed gastric adenocarcinoma ClinicalTrials
MMP9 MARIMASTAT Matrix metalloproteinase 9 inhibitor 3 Completed breast cancer ClinicalTrials
MMP9 MARIMASTAT Matrix metalloproteinase 9 inhibitor 3 Completed lung cancer ClinicalTrials
ClinicalTrials
MMP9 AZD-1236 Matrix metalloproteinase 9 inhibitor 2 Completed chronic obstructive pulmonary disease ClinicalTrials
ClinicalTrials
MMP9 ANDECALIXIMAB Matrix metalloproteinase 9 inhibitor 2 Terminated Crohn's disease ClinicalTrials
MMP9 REBIMASTAT Matrix metalloproteinase 9 inhibitor 2 Completed prostate adenocarcinoma ClinicalTrials
MMP9 ANDECALIXIMAB Matrix metalloproteinase 9 inhibitor 2 Terminated rheumatoid arthritis ClinicalTrials
MMP9 ANDECALIXIMAB Matrix metalloproteinase 9 inhibitor 2 Terminated ulcerative colitis ClinicalTrials
MMP9 CTS-1027 Matrix metalloproteinase 9 inhibitor 2 Completed hepatitis C virus infection ClinicalTrials
ClinicalTrials
MMP9 CTS-1027 Matrix metalloproteinase 9 inhibitor 2 Terminated hepatitis C virus infection ClinicalTrials
MMP9 CTS-1027 Matrix metalloproteinase 9 inhibitor 2 Completed chronic hepatitis C virus infection ClinicalTrials
MMP9 REBIMASTAT Matrix metalloproteinase 9 inhibitor 2 Terminated breast cancer ClinicalTrials
MMP9 REBIMASTAT Matrix metalloproteinase 9 inhibitor 2 Completed lung cancer ClinicalTrials
MMP9 ANDECALIXIMAB Matrix metalloproteinase 9 inhibitor 2 Terminated cystic fibrosis ClinicalTrials
MMP9 AZD-1236 Matrix metalloproteinase 9 inhibitor 2 Withdrawn cystic fibrosis ClinicalTrials
MMP9 ANDECALIXIMAB Matrix metalloproteinase 9 inhibitor 1 Completed chronic obstructive pulmonary disease ClinicalTrials
MMP9 ANDECALIXIMAB Matrix metalloproteinase 9 inhibitor 1 Terminated gastric adenocarcinoma ClinicalTrials
MMP9 ANDECALIXIMAB Matrix metalloproteinase 9 inhibitor 1 Completed rheumatoid arthritis ClinicalTrials
MMP9 REBIMASTAT Matrix metalloproteinase 9 inhibitor 1 Completed sarcoma ClinicalTrials
MMP9 ANDECALIXIMAB Matrix metalloproteinase 9 inhibitor 1 Completed ulcerative colitis ClinicalTrials
ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: