Id: acc0445
Group: 1sens
Protein: AMPK
Gene Symbol: PRKAB1
Protein Id: Q9Y478
Protein Name: AAKB1_HUMAN
PTM: phosphorylation
Site: Thr180
Site Sequence: QKCSDVSELSSSPPGPYHQEP
Disease Category: Cancer
Disease: Colorectal Cancer
Disease Subtype:
Disease Cellline: HT29
Disease Info:
Drug: TPA
Drug Info: -
Relation:
TPA
➜
AMPK-Thr180 DOWN
➜
Colorectal Cancer Aggravate
Effect: modulate
Effect Info: "In low-invasive colon cancer cells, NOX1 expression is high and AMPK is phosphorylated, while TPA treatment leads to increased ROS production, increased NOX2 and MMP–7 expression, and decreased AMPK phosphorylation, inducing an invasive phenotype."
Note:
Score: 4.0
Pubmed(PMID): 26116564
Sentence Index:
Sentence:

Sequence & Structure:

MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
PRKAB1 ACADESINE AMP-activated protein kinase, AMPK activator 3 - cardiovascular disease ATC
PRKAB1 ACADESINE AMP-activated protein kinase, AMPK activator 1 Completed chronic lymphocytic leukemia ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

PRKAB1-Ser101
Cancer Intensity
BRCA
COAD 0.707
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC -0.707
PDAC
UCEC
PRKAB1-Ser108
Cancer Intensity
BRCA -1.494
COAD -0.808
HGSC 2.404
ccRCC -0.429
GBM 0.568
HNSC 0.662
LUAD -0.23
LUSC -0.269
non_ccRCC -0.464
PDAC -0.124
UCEC 0.184
PRKAB1-Ser181
Cancer Intensity
BRCA
COAD -0.707
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
PRKAB1-Ser182
Cancer Intensity
BRCA
COAD -0.707
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
PRKAB1-Ser24
Cancer Intensity
BRCA
COAD -0.484
HGSC 1.485
ccRCC
GBM
HNSC
LUAD -0.33
LUSC
non_ccRCC
PDAC
UCEC -0.672
PRKAB1-Ser40
Cancer Intensity
BRCA 0.814
COAD
HGSC
ccRCC -0.613
GBM -1.812
HNSC 1.42
LUAD 0.127
LUSC 0.046
non_ccRCC -0.974
PDAC 0.177
UCEC 0.815
PRKAB1-Ser49
Cancer Intensity
BRCA 2.169
COAD
HGSC
ccRCC -0.183
GBM -0.211
HNSC 0.744
LUAD -0.979
LUSC -0.771
non_ccRCC 0.02
PDAC -1.027
UCEC 0.238
PRKAB1-Ser94
Cancer Intensity
BRCA
COAD
HGSC
ccRCC 0.707
GBM
HNSC -0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC
PRKAB1-Ser96
Cancer Intensity
BRCA 0.532
COAD 0.368
HGSC -2.188
ccRCC 0.625
GBM
HNSC -1.177
LUAD 0.495
LUSC 0.195
non_ccRCC
PDAC 0.382
UCEC 0.769
PRKAB1-Tyr187
Cancer Intensity
BRCA
COAD -0.707
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: